Biokomposit Hidrogel dengan Ekstrak Centella asiatica sebagai Penutup Luka

نویسندگان

چکیده

Abstract—When wounds occur on skin, cell regeneration and healing process will occur. Imperfect end up leaving ugly scars. Any open have a high chance of being infected, further slowing the processes. The bacteria involved in wound infection are as follow: Pseudomonas aeruginosa, Escherichia coli Staphylococcus aureus. usage current medical adhesive to cover has many implications: cannot be used multiple times untuk may resulting MARSI (Medical Adhesive-Related Skin Injuries). To solve those problems, this research aims find an alternative dressing that able problems mentioned earlier. synthesis biocomposite hydrogel consists bacterial cellulose mixed with gelatin crosslinker agent glutaraldehyde. mixture is then given wild herbs Centella asiatica extract active ingredient. It been found best formulation using 10% gelatine: paste ratio 200:1 total glutaraldehyde concentration 1%. Furthermore, not penetrate human model did exhibit any antimicrobial activity against coli, aureus.
 Keywords: hydrogel, nata de coco, cellulose, gelatine, centella extract, dressing
 Abstrak—Ketika luka terjadi pada kulit, regenerasi sel dan proses penyembuhan akan terjadi. Regenerasi yang tidak sempurna dapat menghasilkan bekas kurang enak dipandang. Selain itu, terbuka berisiko terinfeksi oleh patogen sehingga terhambat. Bakteri berperan infeksi adalah Penggunaan menutup punya banyak kekurangan yaitu penggunaannya bisa dilakukan berulang menyebabkan Injuries), berbagai komplikasi kulit ditempeli dengan produk tersebut. Untuk mengatasi pemasalahan tersebut, penelitian ini bertujuan mendapatkan alternatif penutup terbaru permasalahan telah disebutkan. Pembuatan hidrogel biokomposit terdiri dari selulosa bakteri direaksikan menggunakan agen glutaraldehida. Campuran kemudian ditambahkan bahan aktif ekstrak tanaman liar asiatica. Didapatkan formulasi terbaik perbandingan gelatin:pasta = konsentrasi glutaraldehida sebanyak juga mempenetrasi manusia, serta memiliki aktivitas antibakteri baik Kata kunci: biokomposit, bakteri, gelatin, asiatica,

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ژورنال

عنوان ژورنال: Keluwih

سال: 2022

ISSN: ['2715-6419']

DOI: https://doi.org/10.24123/saintek.v3i1.4907